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U94 alters FN1 and ANGPTL4 gene expression and inhibits tumorigenesis of prostate cancer cell line PC3 by Ekwere T Ifon; Alan LY Pang; Warren Johnson; Kathleen Cashman; Sharon Zimmerman; Sumitra Muralidhar; Wai-Yee Chan; John Casey; Leonard Jason Rosenthal is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is U94 alters FN1 and ANGPTL4 gene expression and inhibits tumorigenesis of prostate cancer cell line PC3 about?
## Background Insensitivity of advanced-stage prostate cancer to androgen ablation therapy is a serious problem in clinical practice because it is associated with aggressive progression and poor prognosis. Targeted therapeutic drug discovery efforts are thwarted by lack of adequate knowledge of gene(s) associated with prostate tumorigenesis. Therefore there is the need for studies to provide leads to targeted intervention measures. Here we propose that stable expression of __U94__, a tumor suppressor gene encoded by human herpesvirus 6A (HHV-6A), could alter gene expression and thereby inhibit the tumorigenicity of PC3 cell line. Microarray gene expression profiling on __U94__ recombinant PC3 cell line could reveal genes that would elucidate prostate cancer biology, and hopefully identify potential therapeutic targets. ## Results We have shown that stable expression of __U94__ gene in PC3 cell line inhibited its focus formation in culture, and tumorigenesis in nude mice. Moreover gene expression profiling revealed dramatic upregulation of __FN 1__ (fibronectin, 91 ± 16-fold), and profound downregulation of __ANGPTL 4__ (angiopoietin-like-4, 20 ± 4-fold) in __U94__ recombinant PC3 c
Who reads U94 alters FN1 and ANGPTL4 gene expression and inhibits tumorigenesis of prostate cancer cell line PC3?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ekwere T Ifon; Alan LY Pang; Warren Johnson; Kathleen Cashman; Sharon Zimmerman; Sumitra Muralidhar; Wai-Yee Chan; John Casey; Leonard Jason Rosenthal
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1475-2867)
- Published
- 2005
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)