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3D printed polylactic acid/gelatin-nano-hydroxyapatite/platelet-rich plasma scaffold for critical-sized skull defect regeneration by Bahraminasab, Marjan (author);Doostmohammadi, Nesa (author);Talebi, Athar (author);Arab, Samaneh (author);Alizadeh, Akram (author);Ghanbari, Ali (author);Salati, Amir (author) is a Medicine article available to read on EtoBox.

What is 3D printed polylactic acid/gelatin-nano-hydroxyapatite/platelet-rich plasma scaffold for critical-sized skull defect regeneration about?

## Abstract ## Background Three-dimensional (3D) printing is a capable approach for the fabrication of bone tissue scaffolds. Nevertheless, a purely made scaffold such as polylactic acid (PLA) may suffer from shortcomings and be restricted due to its biological behavior. Gelatin, hydroxyapatite and platelet-rich plasma (PRP) have been revealed to be of potential to enhance the osteogenic effect. In this study, it was tried to improve the properties of 3D-printed PLA scaffolds by infilling them with gelatin-nano-hydroxyapatite (PLA/G-nHA) and subsequent coating with PRP. For comparison, bare PLA and PLA/G-nHA scaffolds were also fabricated. The printing accuracy, the scaffold structural characterizations, mechanical properties, degradability behavior, cell adhesion, mineralization, systemic effect of the scaffolds on the liver enzymes, osteocalcin level in blood serum and in vivo bone regeneration capability in rat critical-sized calvaria defect were evaluated. ## Results High printing accuracy (printing error of < 11%) was obtained for all measured parameters including strut thickness, pore width, scaffold density and porosity%. The highest mean ultimate compression strength (UCS)

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Author
Bahraminasab, Marjan (author);Doostmohammadi, Nesa (author);Talebi, Athar (author);Arab, Samaneh (author);Alizadeh, Akram (author);Ghanbari, Ali (author);Salati, Amir (author)
Publisher
Springer Science and Business Media LLC
Published
2022
Language
EN
Field
Medicine (Health Sciences)

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