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L-iduronic Acid, a Major Constituent of Heparin by A.S. Perlin; G.R. Sanderson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## ABSTEL4CT Heparin has been degraded by a sequence of several reactions to give as the major identifiable products, 1,6-anhydro-L-idopyranose (2) and 2,5-anhydro-Dmannitol (3), these products bein g attributed originally to L-idosyluronic acid and the 2-amino-2-deoxy-D-glucopyranosyl residues, respectively. Products such as methyl a-D-glucopyranoside (4), derivable from D-glucosyluronic acid residues, were relatively minor, the ratio of 2 to 3 to 4 being approximately 5:5: 1. These findings are supported by periodate-oxidation experiments, which have led to the detection of threitol (5 parts) and erythritol (1 part). The latter results show also that the I\_-idosyluronic (as well as the D-glucosyluronic) acid residues are substituted at position 4, and other evidence indicates that a hexosaminyl residue frequently is the 4-substituent. By reducing carboxyl groups of heparin (as methyl esters) with borohydride in tritiated water, evidence has been obtained to indicate that little, if any, of 2 is derived through isomerization of D-glucosyluronic acid residues. By contrast, and as required by the above information, the use of borohydride-t affords isotopically labelled 2. It is sug

Who reads L-iduronic Acid, a Major Constituent of Heparin?

Author

A.S. Perlin; G.R. Sanderson

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0008-6215)

Published

1970

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)