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Age and Growth Factors in Porcine Full-thickness Wound Healing by Feng Yao; Scott Visovatti; C. Starck Johnson; Michael Chen; Jaromir Slama; Andreas Wenger; Elof Eriksson is a Medicine article available to read on EtoBox.

What is Age and Growth Factors in Porcine Full-thickness Wound Healing about?

It has been recognized that the rate of cutaneous wound healing declines with age, yet the molecular processes that affect this decline remain poorly understood. The purpose of this study was to compare reepithelialization and contraction rates, and growth factor profiles in full‐thickness wounds in swine of various ages. Multiple full‐thickness excisional wounds were created on the dorsum of 24‐month‐old (n=2), 4‐month‐old (n=2), and 2‐month‐old (n=2) Yucatan Minipigs. The extent of reepithelialization was shown to decrease with increasing age in a manner that was statistically significant among the 2‐month‐old (79%), 4‐month‐old (48%), and 24‐month‐old pigs (22%). Enzyme‐linked immunosorbent assay results showed that endogenous vascular endothelial growth factor concentrations in the 2‐ and 4‐month‐old animals peaked on day 4, reaching levels of 482 pg/ml and 420 pg/ml, respectively. In the 24‐month‐old pigs the vascular endothelial growth factor concentration peaked later (day 6), and was present at a lower level (229 pg/ml). On day 4 the vascular endothelial growth factor levels in the older pigs reached only 120 pg/ml, representing a four‐fold decrease in concentration compare

Who reads Age and Growth Factors in Porcine Full-thickness Wound Healing?

Author

Feng Yao; Scott Visovatti; C. Starck Johnson; Michael Chen; Jaromir Slama; Andreas Wenger; Elof Eriksson

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1067-1927)

Published

2001

Language

EN

Field

Medicine (Health Sciences)