Can I read Structural Support of Hair Cell Transduction : Freeze-fracture-etching of the Sensory Epithelia of the Inner Ear on EtoBox?

Structural Support of Hair Cell Transduction : Freeze-fracture-etching of the Sensory Epithelia of the Inner Ear by Andrew Forge is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Structural Support of Hair Cell Transduction : Freeze-fracture-etching of the Sensory Epithelia of the Inner Ear about?

## Freeze-fracture-etching of the Sensory Epithelia of the Inner Ear Transduction of sound is dependent upon the organisation of the cytoskeletal structures that form and support the stereociliary bundle of cochlear hair cells. Freeze-fracture followed by deep etching reveals the organisation of the hair cell cytoskeleton and indicates how mechanical support for stereocilia is provided. This can offer explanations of why mutations in certain genes that are widely expressed in the body have effects only upon the functioning of auditory hair cells to cause non-syndromic deafness. on a platform, the "cuticular plate" in the apical cytoplasm of the hair cell (fig. 1b). The cuticular plate, which appears relatively unstructured in thin sections (fig. 1b), is composed of actin with a variety of actin-interacting proteins [3]. More recently, analysis of the mutations in a number of different genes that cause hereditary deafness has identified several other cytoskeletal proteins that are essential to the formation and maintenance of the transduction apparatus [4]. Identifying how these proteins are organised and interact structurally is crucial to understanding how hair cells work and how

Who reads Structural Support of Hair Cell Transduction : Freeze-fracture-etching of the Sensory Epithelia of the Inner Ear?

Author

Andrew Forge

Publisher

Wiley (John Wiley & Sons); Wiley (ISSN 1439-4243)

Published

2007

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Physical Sciences)