About this document
Acepromazine Inhibits HERG Potassium Ion Channels Expressed in Human Embryonic Kidney 293 Cells by edunovakoski is a document available to read on EtoBox.
This study investigates the effects of acepromazine on hERG potassium channels in human embryonic kidney cells, revealing that acepromazine inhibits hERG currents in a concentration-dependent manner with an IC50 value of 1.5 μM. The drug blocks hERG currents in a voltage-dependent manner, indicating a higher affinity for the open state of the channels. These findings suggest that acepromazine may pose a risk for cardiac arrhythmias due to its inhibition of hERG channels, which are crucial for cardiac rhythm
- Author
- edunovakoski
- Language
- EN