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Can the Leukocyte Esterase Strip Test Predict Persistence of Periprosthetic Joint Infection at Second-Stage Reimplantation? by Nicola Logoluso; Antonio Pellegrini; Virginia Suardi; Ilaria Morelli; Antonino Giulio Battaglia; Roberto D’Anchise; Elena De Vecchi; Luigi Zagra is a Medicine article available to read on EtoBox.
What is Can the Leukocyte Esterase Strip Test Predict Persistence of Periprosthetic Joint Infection at Second-Stage Reimplantation? about?
## Background: We evaluated the reliability of intraoperative assessment of leukocyte esterase (le) in synovial fluid samples from patients undergoing reimplantation following implant removal and spacer insertion for periprosthetic joint infection (pji). our hypothesis was that a positive intraoperative le test would be a better predictor of persistent infection than either serum c-reactive protein (crp) or erythrocyte sedimentation rate (esr) or the combination of serum crp and esr. ## Methods: The records of 76 patients who received a 2-stage exchange for pji were retrospectively reviewed. synovial fluid was collected for le measurement during surgery before arthrotomy in 79 procedures. receiver operating characteristic curves were generated. sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and area under the curve (auc) of le, crp, esr, and crp + esr were calculated. ## Results: Sensitivity, specificity, positive predictive value, and negative predictive value of the le assay were 82%, 99%, 90%, and 97%, respectively. receiver operating characteristic analysis revealed an le threshold of 1.5 between the first (negative) and the second (po
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- Author
- Nicola Logoluso; Antonio Pellegrini; Virginia Suardi; Ilaria Morelli; Antonino Giulio Battaglia; Roberto D’Anchise; Elena De Vecchi; Luigi Zagra
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)