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Observations of cardiac beating behaviors of wild-type and mutant Drosophilae with optical coherence tomography by Meng-Tsan Tsai; Feng-Yu Chang; Cheng-Kuang Lee; Ting-Ta Chi; Kai-Min Yang; Lian-Yu Lin; June-Tai Wu; C. C. Yang is a Engineering article available to read on EtoBox.

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## Abstract Time‐resolved optical coherence tomography (OCT) scanning images of wild‐type and mutant fruit flies (__Drosophila melanogaster__), illustrating the heartbeat patterns for evaluating their cardiac functions, are demonstrated. Based on the heartbeat patterns, the beat rate and the relative phase between the first two heart segments can be evaluated. The OCT scanning results of mutant flies with impaired proteasome function in cardiac muscles show irregular heartbeat patterns and systematically decreased average beat rates, when compared with the regular patterns of ∼4.97 beats/s in average beat rate of the wild‐type. In both wild‐type and proteasome mutant flies, the beatings at different locations in the same heart segment are essentially synchronized. However, between different heart segments, although the beating in the second segment shows a lag in phase behind that of the first segment in a wild‐type, in a proteasome mutant, the beating in the second segment becomes significantly leading that of the first segment. Besides the comparison between the wild‐type and proteasomal mutant flies, the influences of using different methods for immobilizing flies during OCT sca

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Author

Meng-Tsan Tsai; Feng-Yu Chang; Cheng-Kuang Lee; Ting-Ta Chi; Kai-Min Yang; Lian-Yu Lin; June-Tai Wu; C. C. Yang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley - VCH Verlag GmbH & CO. KGaA; Wiley (ISSN 1864-063X)

Published

2011

Language

EN

Field

Engineering (Physical Sciences)