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Effectiveness of 7-Valent Pneumococcal Conjugate Vaccine Against Invasive Pneumococcal Disease in Medically At-Risk Children in Australia: A Record Linkage Study by Alamgir Kabir; Anthony T Newall; Deborah Randall; Hannah C Moore; Sanjay Jayasinghe; Parveen Fathima; Bette Liu; Peter McIntyre; Heather F Gidding is a Medicine article available to read on EtoBox.
What is Effectiveness of 7-Valent Pneumococcal Conjugate Vaccine Against Invasive Pneumococcal Disease in Medically At-Risk Children in Australia: A Record Linkage Study about?
## Abstract ## Background Children with chronic medical conditions are at higher risk of invasive pneumococcal disease (IPD), but little is known about the effectiveness of the primary course of pneumococcal conjugate vaccine (PCV) in these children. ## Methods A cohort born in 2001–2004 from two Australian states and identified as medically at-risk (MAR) of IPD either using ICD-coded hospitalizations (with conditions of interest identified by 6 months of age) or linked perinatal data (for prematurity) were followed to age 5 years for notified IPD by serotype. We categorized fully vaccinated children as either receiving PCV dose 3 by <12 months of age or ≥1 PCV dose at ≥12 months of age. Cox proportional hazard modeling was used to estimate hazard ratios (HRs), adjusted for confounders, and vaccine effectiveness (VE) was estimated as (1-HR) × 100. ## Results A total of 9220 children with MAR conditions had 53 episodes of IPD (43 vaccine-type); 4457 (48.3%) were unvaccinated and 4246 (46.1%) were fully vaccinated, with 1371 (32.3%) receiving dose 3 by 12 months and 2875 (67.7%) having ≥1 dose at ≥12 months. Estimated VE in fully vaccinated children was 85.9% (95% CI: 33.9–97.0) agai
Who reads Effectiveness of 7-Valent Pneumococcal Conjugate Vaccine Against Invasive Pneumococcal Disease in Medically At-Risk Children in Australia: A Record Linkage Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Alamgir Kabir; Anthony T Newall; Deborah Randall; Hannah C Moore; Sanjay Jayasinghe; Parveen Fathima; Bette Liu; Peter McIntyre; Heather F Gidding
- Publisher
- Oxford University Press (OUP)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)