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What is USP43 about?

This study investigates the role of ubiquitin-specific protease 43 (USP43) in ovarian cancer, revealing that USP43 promotes tumor progression by suppressing ferroptosis through the stabilization of fatty acid synthase (FASN) and activation of SLC7A11. High USP43 expression correlates with poor prognosis in ovarian cancer patients, and targeting the USP43-FASN-HIF1α-SLC7A11 axis may enhance platinum sensitivity in treatment. The findings suggest that USP43 could serve as a potential therapeutic target for ov

Author

费禹翔

Language

EN