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Review of Proteomics with Applications to Genetic Epidemiology by Thomas A. Sellers; John R. Yates is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Mapping of the human genome has the potential to transform the traditional methods of genetic epidemiology. The complete draft sequence of the 3.3 billion nucleotides comprising the genome is now available over the Internet, including the location and nearly complete sequence of the 26,000 to 31,000 protein‐encoding genes. However, aside from water, almost everything in the human body is either made of, or by, proteins. Although the DNA code provides the instructions for their amino acid sequence, there are an estimated 1.5 million proteins. Thus, the correlation between DNA sequence and protein is low, reflecting alternate splicing as well as post‐translational modification. The purpose of this article is to explore ways in which the emerging field of __proteomics__, the study of proteins in a cell, may inform our approach to gene mapping. This article reviews the various technical approaches currently available for proteomics. Technologies are available to quantify protein expression (and compare normal versus disease states), identify proteins through comparison with sequence information in databases or direct sequencing (which can then be mapped to chromosomal locat

Who reads Review of Proteomics with Applications to Genetic Epidemiology?

Author

Thomas A. Sellers; John R. Yates

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0395)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)