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Redox Modulation of Mitochondrial Proteins in the Neurotoxicant Models of Parkinson's Disease by Alika Sarkar; Mohd Sami Ur Rasheed; Mahendra Pratap Singh is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Redox Modulation of Mitochondrial Proteins in the Neurotoxicant Models of Parkinson's Disease about?

Significance: Mitochondrial proteins regulate the oxidative phosphorylation, cellular metabolism, and free radical generation. Redox modulation alters the mitochondrial proteins and instigates the damage to dopaminergic neurons. Toxicants contribute to Parkinson's disease (PD) pathogenesis in conjunction with aging and genetic factors. While oxidative modulation of a number of mitochondrial proteins is linked to xenobiotic exposure, little is known about its role in the toxicant-induced PD. Understanding the role of redox modulation of mitochondrial proteins in complex cellular events leading to neurodegeneration is highly relevant. Recent Advances: Many toxicants are shown to inhibit complex I or III and elicit free radical production that alters the redox status of mitochondrial proteins. Implication of redox modulation of the mitochondrial proteins makes them a target to comprehend the underlying mechanism of toxicant-induced PD. Critical Issues: Owing to multifactorial etiology, exploration of onset and progression and treatment outcomes needs a comprehensive approach. The article explains about a few mitochondrial proteins that undergo redox changes along with the promising st

Who reads Redox Modulation of Mitochondrial Proteins in the Neurotoxicant Models of Parkinson's Disease?

Author

Alika Sarkar; Mohd Sami Ur Rasheed; Mahendra Pratap Singh

Publisher

Mary Ann Liebert Inc

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)