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What is CYP2C19 Genetic Variants in PPI Metabolism about?

CYP2C19 is an enzyme involved in the metabolism of proton pump inhibitors (PPIs). It exhibits genetic polymorphisms that result in interindividual variability in PPI pharmacokinetics. The CYP2C19 gene is located on chromosome 10 and encodes a 490 amino acid protein expressed in the liver and intestines. Genetic variants such as CYP2C19*2,*3, and *17 affect enzyme activity and classify individuals as rapid, intermediate, or poor metabolizers of PPIs. Poor metabolizer status results in higher PPI bioavailabil

Author

Ashish Satyal

Language

EN