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## Summary Enzyme immunoassays have been used to detect __Helicobacter pylori__ infection in human body materials such as faeces, urine and saliva. The stool antigen assay (HpSA), which uses polyclonal anti‐__H. pylori__ antibody as a capture reagent, has been widely used in the pre‐treatment diagnosis of the infection in adults and children. Although the assay has the potential for monitoring eradication therapy, there are controversies over its use, especially at an early stage after treatment. The efficacy of the stool antigen assay can be modified by using monoclonal antibodies towards well characterized __H. pylori__ faecal antigens. Two types of enzyme immunoassays (enzyme‐linked immunosorbent assay [ELISA] and immunochromatography) have been used to detect antibodies to __H. pylori__ in urine. Immunochromatography of urine is a rapid assay well suited for epidemiological studies. The salivary ELISA, used in a number of studies, has shown inconsistent results with less than optimum sensitivity and specificity. Urinary and salivary immunoassays may not distinguish between past and present infections, thus limiting their potential to monitor eradication therapy.

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Author

S. Kabir

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

2003

Language

EN

Field

Medicine (Health Sciences)