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What is SMSD Approach for Itraconazole Absorption about?

This document discusses a study that aimed to avoid variations in the oral absorption of the drug itraconazole (ITZ) caused by food intake using a self-micellizing solid dispersion (SMSD) approach. The study evaluated the dissolution behavior of crystalline ITZ and SMSD/ITZ under fasted and fed conditions and assessed the pharmacokinetics of orally administered ITZ in fasted and fed rats. The results showed that SMSD/ITZ suppressed the food effect on ITZ dissolution and absorption, exhibiting consistent pha

Author

Shimul Halder

Language

EN