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Can I read Aliphatic replacements of the biphenyl moiety of the nonpeptidyl growth hormone secretagogues L-692,429 and L-692,585 on EtoBox?
Aliphatic replacements of the biphenyl moiety of the nonpeptidyl growth hormone secretagogues L-692,429 and L-692,585 by Lin Chu; Helmut Mrozik; Michael H. Fisher; Jeannette E. Brown; Kang Cheng; Wanda W.-S. Chan; William R. Schoen; Matthew J. Wyvratt; Bridget S. Butler; Roy G. Smith is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Aliphatic replacements of the biphenyl moiety of the nonpeptidyl growth hormone secretagogues L-692,429 and L-692,585 about?
Replacement of the central phenyl ring of the biphenyl moiety in the novel growth hormone (GH) secretagogues L-692,429 and L-692,585 with partially or completely saturated surrogates has been investigated. The cyclohexenyl analogue 37 displayed GH releasing activity comparable to L-692,585, indicating that the aromaticity of this central ring is not critical for bioactivity and that this ring may serve primarily to orient the benzolactam and phenyltetrazole pharmacophores.
Who reads Aliphatic replacements of the biphenyl moiety of the nonpeptidyl growth hormone secretagogues L-692,429 and L-692,585?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Lin Chu; Helmut Mrozik; Michael H. Fisher; Jeannette E. Brown; Kang Cheng; Wanda W.-S. Chan; William R. Schoen; Matthew J. Wyvratt; Bridget S. Butler; Roy G. Smith
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 1995
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)