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Can I read An overview of signaling pathways regulating YAP/TAZ activity on EtoBox?
An overview of signaling pathways regulating YAP/TAZ activity by Boon Chin Heng; Xuehui Zhang; Dominique Aubel; Yunyang Bai; Xiaochan Li; Yan Wei; Martin Fussenegger; Xuliang Deng is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is An overview of signaling pathways regulating YAP/TAZ activity about?
YAP and TAZ are ubiquitously expressed homologous proteins originally identified as penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining mammalian tissue/organ size. Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing. In this review, we first examine the various microenvironmental cues and signaling pathways that regulate YAP/TAZ activation, through the Hippo and non-Hippo signaling pathways. This is followed by a brief summary of the interactions of YAP/TAZ with TEAD1-4 and a diverse array of other non-TEAD transcription factors. Finally, we offer a critical perspective on how increasing knowledge of the regulatory mechanisms of YAP/TAZ signaling might open the door to novel therapeutic applications in the interrelated fields of biomaterials, tissue engineering, regenerative medicine and synthetic biology.
Who reads An overview of signaling pathways regulating YAP/TAZ activity?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Boon Chin Heng; Xuehui Zhang; Dominique Aubel; Yunyang Bai; Xiaochan Li; Yan Wei; Martin Fussenegger; Xuliang Deng
- Publisher
- Springer Science and Business Media LLC
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)