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Can I read Cutting Edge: Activation-Induced Iron Flux Controls CD4 T Cell Proliferation by Promoting Proper IL-2R Signaling and Mitochondrial Function on EtoBox?
Cutting Edge: Activation-Induced Iron Flux Controls CD4 T Cell Proliferation by Promoting Proper IL-2R Signaling and Mitochondrial Function by Emily L. Yarosz; Chenxian Ye; Ajay Kumar; Chauna Black; Eun-Kyung Choi; Young-Ah Seo; Cheong-Hee Chang is a Immunology and Microbiology article available to read on EtoBox.
What is Cutting Edge: Activation-Induced Iron Flux Controls CD4 T Cell Proliferation by Promoting Proper IL-2R Signaling and Mitochondrial Function about?
## Abstract Iron has long been established as a critical mediator of T cell development and proliferation. However, the mechanisms by which iron controls CD4 T cell activation and expansion remain poorly understood. In this study, we show that stimulation of CD4 T cells from C57BL/6 mice not only decreases total and labile iron levels but also leads to changes in the expression of iron homeostatic machinery. Additionally, restraining iron availability in vitro severely inhibited CD4 T cell proliferation and cell cycle progression. Although modulating cellular iron levels increased IL-2 production by activated T lymphocytes, CD25 expression and pSTAT5 levels were decreased, indicating that iron is necessary for IL-2R–mediated signaling. We also found that iron deprivation during T cell stimulation negatively impacts mitochondrial function, which can be reversed by iron supplementation. In all, we show that iron contributes to activation-induced T cell expansion by positively regulating IL-2R signaling and mitochondrial function.
Who reads Cutting Edge: Activation-Induced Iron Flux Controls CD4 T Cell Proliferation by Promoting Proper IL-2R Signaling and Mitochondrial Function?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Emily L. Yarosz; Chenxian Ye; Ajay Kumar; Chauna Black; Eun-Kyung Choi; Young-Ah Seo; Cheong-Hee Chang
- Publisher
- The American Association of Immunologists
- Published
- 2020
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)