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Can I read Necroptosis in the Developing Brain: Role in Neurodevelopmental Disorders on EtoBox?
Necroptosis in the Developing Brain: Role in Neurodevelopmental Disorders by Nnenna Loveth Anosike; Joy Funsho Adejuwon; Godslove Emeka Emmanuel; Oluwatosin Samuel Adebayo; Hassanat Etti-Balogun; Jannie Nathaniel Nathaniel; Omolabake Ifeoluwa Omotosho; Michael Aschner; Omamuyovwi Meashack Ijomone is a Medicine article available to read on EtoBox.
What is Necroptosis in the Developing Brain: Role in Neurodevelopmental Disorders about?
Cell death is vital to various organismal developmental processes including brain development. Apoptosis, the most recognized programmed cell death, has been linked to several developmental processes and implicated in pruning cells to provide the ultimate tissue integrity. However, more recently, other forms of non-apoptotic programmed cell death have been identified, of which necroptosis is of predominant interest. Necroptosis is a regulated form of necrosis, activated under apoptotic-deficient conditions. Tumour necrosis factor (TNF) is a major activator of necroptosis, and the process is mediated by several kinases including receptor-interacting protein kinase (RIPK) and mixed lineage kinase domainlike protein (MLKL). Potential roles for necroptosis during brain development have been muted. Necroptosis has been implicated in mediating neurological disorders, and contributing to the severity of these disorders. Here we will review the literature on the role of necroptosis in neurodevelopment, summarizing its molecular mechanisms and highlighting potential implications for disorders of the developing brain.
Who reads Necroptosis in the Developing Brain: Role in Neurodevelopmental Disorders?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Nnenna Loveth Anosike; Joy Funsho Adejuwon; Godslove Emeka Emmanuel; Oluwatosin Samuel Adebayo; Hassanat Etti-Balogun; Jannie Nathaniel Nathaniel; Omolabake Ifeoluwa Omotosho; Michael Aschner; Omamuyovwi Meashack Ijomone
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Life Sciences)