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Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core by Zhao, Haiyan (author);Young, Natalie (author);Kalchschmidt, Jens (author);Lieberman, Jenna (author);El Khattabi, Laila (author);Casellas, Rafael (author);Asturias, Francisco J. (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The Mediator complex plays an essential and multi-faceted role in regulation of RNA polymerase II transcription in all eukaryotes. Structural analysis of yeast Mediator has provided an understanding of the conserved core of the complex and its interaction with RNA polymerase II but failed to reveal the structure of the Tail module that contains most subunits targeted by activators and repressors. Here we present a molecular model of mammalian (Mus musculus) Mediator, derived from a 4.0 Å resolution cryo-EM map of the complex. The mammalian Mediator structure reveals that the previously unresolved Tail module, which includes a number of metazoan specific subunits, interacts extensively with core Mediator and has the potential to influence its conformation and interactions.

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Author

Zhao, Haiyan (author);Young, Natalie (author);Kalchschmidt, Jens (author);Lieberman, Jenna (author);El Khattabi, Laila (author);Casellas, Rafael (author);Asturias, Francisco J. (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)