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ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study by Eirini V. Theodoraki; Tiit Nikopensius; Julia Suhorutšenko; Vassileios Papamikos; Genovefa D. Kolovou; Vassileios Peppes; Demosthenes Panagiotakos; Sasa Limberi; Nikolaos Zakopoulos; Andres Metspalu; George V. Dedoussis is a Medicine article available to read on EtoBox.
What is ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study about?
Background: Rs619203 (Cys2229Ser) and rs529038 (Asp2213Asn) polymorphisms in the ROS1 gene have been studied in relation to myocardial infarction (MI) yielding inconsistent results. We investigated the role of ROS1 rs529038 polymorphism in coronary artery disease (CAD) in Greeks using a case-control study. Methods: Genotyping for rs529038 polymorphism was performed using a multiplex PCR technique in patients with CAD (ns294) and controls (ns311). Logistic regression analysis was used to calculate crude and adjusted odds ratios (ORs). Results: Logistic regression analysis did not show any statistically significant effect of ROS1 polymorphism in the occurrence of CAD (AG vs. AA, OR: 1.08, ps0.635; GG vs. AA, OR: 0.62, ps0.220). Adjustment for confounding factors gave similar results, irrespective of the type of disease (i.e., stable coronary artery disease vs. acute coronary syndrome). Conclusions: Our findings do not support the hypothesis that ROS1 rs529038 polymorphism is an important contributing factor in the etiology of CAD in the Greek population.
Who reads ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study?
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- Author
- Eirini V. Theodoraki; Tiit Nikopensius; Julia Suhorutšenko; Vassileios Papamikos; Genovefa D. Kolovou; Vassileios Peppes; Demosthenes Panagiotakos; Sasa Limberi; Nikolaos Zakopoulos; Andres Metspalu; George V. Dedoussis
- Publisher
- Walter de Gruyter GmbH
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)