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Evaluation of the antioxidant, DNA interaction and tumor cell cytotoxicity activities of Copper(II) complexes with Paeonol Schiff-base by Dong-Dong Qin; Zheng-Yin Yang; Fu-Hong Zhang; Bo Du; Ping Wang; Tian-Rong Li is a Materials Science article available to read on EtoBox.

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Herein, we report for the first time on the preparation of four Paeonol Schiff-base ligands: 1,2-Bis(2hydroxy-4-methoxy-α-methylbenzylideneimino) ethane (H 2 L 1 ), 2-hydroxy-4-methoxy-α-methylbenzylidene (benzoyl) hydrazone (HL 2 ), 2-hydroxy-4-methoxyacetophenone-ethanolamine Schiff-base (HL 3 ), and 2-hydroxy-4-methoxyacetophenone(2′-hydroxybenzoyl) hydrazone (H 2 L 4 ), and their Cu(II) complexes, of which the structure of C 11 N 2 O 6 H 14 Cu(CuL 3. NO 3 ) was confirmed by X-ray diffraction. Antioxidant activities of four Cu(II) complexes were studied by the standard non-enzymatic NBT method and Fenton system, used to produce superoxide anion radicals and hydroxyl radicals, respectively. The results show these Cu(II) complexes have excellent antioxidant activities. DNA-binding and in vitro cytotoxicity experiments were utilized to further investigate the biological activities of C 11 N 2 O 6 H 14 Cu(CuL 3. NO 3 ). These results support C 11 N 2 O 6 H 14 Cu as a potential candidate for biological use because it shows not only high antioxidant and moderate DNA-binding activities, but also good tumor cell cytotoxicity activities in human cell lines carcinomas Hep-2 (larynx), for

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Author

Dong-Dong Qin; Zheng-Yin Yang; Fu-Hong Zhang; Bo Du; Ping Wang; Tian-Rong Li

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1387-7003)

Published

2010

Language

EN

Field

Materials Science (Physical Sciences)