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Human Chondrosarcoma Secretes Vascular Endothelial Growth Factor to Induce Tumor Angiogenesis and Stores Basic Fibroblast Growth Factor for Regulation of Its Own Growth by Takayuki Furumatsu; Keiichiro Nishida; Akira Kawai; Masayoshi Namba; Hajime Inoue; Yoshifumi Ninomiya is a Medicine article available to read on EtoBox.

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## Abstract Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are well‐known factors that induce neovascularization in many tumors. The molecular mechanisms that regulate tumor angiogenesis in human chondrosarcoma are not clear. We assessed in this work the angiogenic activities of a human chondrosarcoma cell line (OUMS‐27) __in vivo__ and determined the efficacies of angiogenic factors derived from OUMS‐27 cells on human umbilical vein endothelial cells (HUVECs) __in vitro__. Tumor xenografts induced an increase in the formation of neovessels, but the distributions of Ki‐67 antigen, VEGF and bFGF were unaffected. We also demonstrated that OUMS‐27 cells secreted VEGF~165~ into the culture medium and that it was the maximal angiogenic factor to stimulate endothelial proliferation and migration in chondrosarcoma. Anti‐VEGF antibodies induced an approximately 70% inhibition of these responses of HUVECs, but did not have any effect on OUMS‐27 cells. Anti‐bFGF antibodies suppressed not only the activities of HUVECs but also the growth of tumor cells __in vitro__. We indicate that angiogenesis is principally elicited by VEGF~165~ and that tumorigenesis i

Who reads Human Chondrosarcoma Secretes Vascular Endothelial Growth Factor to Induce Tumor Angiogenesis and Stores Basic Fibroblast Growth Factor for Regulation of Its Own Growth?

Author

Takayuki Furumatsu; Keiichiro Nishida; Akira Kawai; Masayoshi Namba; Hajime Inoue; Yoshifumi Ninomiya

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2001

Language

EN

Field

Medicine (Health Sciences)