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Can I read Cytotoxic Effects on Cancerous and Non-cancerous Cells of Trans -Cinnamaldehyde, Carvacrol, and Eugenol on EtoBox?

Cytotoxic Effects on Cancerous and Non-cancerous Cells of Trans -Cinnamaldehyde, Carvacrol, and Eugenol by Ranjitkar, Saurav (author);Zhang, Delong (author);Sun, Fei (author);Salman, Saleh (author);He, Wu (author);Venkitanarayanan, Kumar (author);Tulman, Edan R. (author);Tian, Xiuchun (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Cytotoxic Effects on Cancerous and Non-cancerous Cells of Trans -Cinnamaldehyde, Carvacrol, and Eugenol about?

Essential oils and their active components, referred here as plant derived antimicrobials (PDAs), have been used for their antimicrobial, anti-inflammatory and antioxidant properties. Many reports also document PDAs’ cytotoxic effects on cancerous cells, raising the hope that they could be used for cancer treatments. Due to the lack of specificity, we hypothesize that PDAs are cytotoxic to both cancerous and non-cancerous cells. __Trans__-cinnamaldehyde (TCA), carvacrol, and eugenol were assessed for their cytotoxicity on cancerous HeLa cells and normal skin fibroblasts (CCD-1123Sk, CCD) by MTT and LDH assays, flow cytometry, and reverse transcription quantitative PCR (RT-qPCR). After 24 h of treatment, carvacrol and TCA significantly decreased cell viability (by more than 50%) at 100 μg/ml, whereas eugenol was ineffective up to 400 μg/ml. Cell detachment and significantly increased apoptosis were observed with 100 μg/ml of TCA on both cell types. RT-qPCR for apoptotic genes (__BCL2, CASP3 and CASP8__) and necrosis genes (__MLKL, RIPK1 and RIPK3__) did not show significant differences between control and treated cells of both types, with the exception of eugenol-treated HeLa cells

Who reads Cytotoxic Effects on Cancerous and Non-cancerous Cells of Trans -Cinnamaldehyde, Carvacrol, and Eugenol?

It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.

Author
Ranjitkar, Saurav (author);Zhang, Delong (author);Sun, Fei (author);Salman, Saleh (author);He, Wu (author);Venkitanarayanan, Kumar (author);Tulman, Edan R. (author);Tian, Xiuchun (author)
Publisher
Springer Science and Business Media LLC
Published
2021
Language
EN
Field
Biochemistry, Genetics and Molecular Biology (Life Sciences)

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