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Calcium Channel Blocker Use and Outcomes in Patients with Heart Failure and Mildly Reduced and Preserved Ejection Fraction by Shingo Matsumoto; Toru Kondo; Mingming Yang; Ross T. Campbell; Kieran F. Docherty; Rudolf A. de Boer; Akshay S. Desai; Carolyn S.P. Lam; Milton Packer; Bertram Pitt; Jean L. Rouleau; Muthiah Vaduganathan; Faiez Zannad; Michael R. Zile; Scott D. Solomon; Pardeep S. Jhund; John J.V. McMurray is a Medicine article available to read on EtoBox.
What is Calcium Channel Blocker Use and Outcomes in Patients with Heart Failure and Mildly Reduced and Preserved Ejection Fraction about?
## Abstract ## Aims Patients with heart failure (HF) and mildly reduced ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF) are often treated with calcium channel blockers (CCBs), although the safety of CCBs in these patients is uncertain. We aimed to investigate the association between CCB use and clinical outcomes in patients with HFmrEF/HFpEF; CCBs were examined overall, as well as by subtype (dihydropyridine and non‐dihydropyridine). ## Methods and results We pooled individual patient data from four large HFpEF/HFmrEF trials. The association between CCB use and outcomes was assessed. Among the 16 954 patients included, the mean left ventricular ejection fraction (LVEF) was 56.8%, and 13 402 (79.0%) had HFpEF (LVEF ≥50%). Altogether, 5874 patients (34.6%) received a CCB (87.6% dihydropyridines). Overall, the risks of death and HF hospitalization were not higher in patients treated with a CCB, particularly dihydropyridines. The risk of pump failure death was significantly lower (hazard ratio [HR] 0.76, 95% confidence interval [CI] 0.60–0.96), while the risk of stroke was higher (HR 1.26, 95% CI 1.06–1.50) in patients treated with a CCB compared to those not. These
Who reads Calcium Channel Blocker Use and Outcomes in Patients with Heart Failure and Mildly Reduced and Preserved Ejection Fraction?
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- Author
- Shingo Matsumoto; Toru Kondo; Mingming Yang; Ross T. Campbell; Kieran F. Docherty; Rudolf A. de Boer; Akshay S. Desai; Carolyn S.P. Lam; Milton Packer; Bertram Pitt; Jean L. Rouleau; Muthiah Vaduganathan; Faiez Zannad; Michael R. Zile; Scott D. Solomon; Pardeep S. Jhund; John J.V. McMurray
- Publisher
- Wiley
- Published
- 2023
- Field
- Medicine (Health Sciences)