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Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer by Ping Yuan; Liwei Wang; Daoyan Wei; Jun Zhang; Zhiliang Jia; Qiang Li; Xiangdong Le; Huamin Wang; James Yao; Keping Xie is a Medicine article available to read on EtoBox.
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## Abstract ## BACKGROUND Human pancreatic cancer over expresses the transcription factor Sp1. However, the role of Sp1 in pancreatic cancer angiogenesis and its use as target for antiangiogenic therapy remain unexplored. ## METHODS Archived human pancreatic cancer specimens were used to assess gene expression and microvessel density (MVD) status by immunohistochemistry: Small‐interfering RNA (siRNA) was used to determine the impact of altered Sp1 expression on tumor growth and angiogenesis, and mithramycin A (MIT) was used to evaluate Sp1‐targeted antiangiogenic treatment of human pancreatic cancer in animal models. ## RESULTS The expression level of Sp1 was correlated directly with the MVD status (__P__ < .001) and the expression level of vascular endothelial growth factor (VEGF) (__P__ < .05). Knockdown of Sp1 expression did not affect the growth of pancreatic cancer cells in vitro but inhibited their growth and metastasis in mouse models. This antitumor activity was consistent with the in vitro and in vivo antiangiogenic activity resulting from Sp1 knockdown. Subcutaneous and intraperitoneal injection of MIT significantly suppressed the growth of human pancreatic cancer in mous
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- Author
- Ping Yuan; Liwei Wang; Daoyan Wei; Jun Zhang; Zhiliang Jia; Qiang Li; Xiangdong Le; Huamin Wang; James Yao; Keping Xie
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)