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Can I read Genetic epidemiology of visceral leishmaniasis in northeastern Brazil on EtoBox?
Genetic epidemiology of visceral leishmaniasis in northeastern Brazil by C.S. Peacock; A. Collins; M.-A. Shaw; F. Silveira; J. Costa; C.H. Coste; M.D. Nascimento; R. Siddiqui; J.J. Shaw; J.M. Blackwell is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Genetic epidemiology of visceral leishmaniasis in northeastern Brazil about?
Familial clustering of disease, racial differences in asymptomatic:disease ratios, and studies of mice all point to a genetic component for disease susceptibility in visceral leishmaniasis. Analysis of 87 multi-case pedigrees (824 individuals; 138 nuclear families) from a region of northeastern Brazil endemic for Leishmania chagasi demonstrates a high relative risk ratio (lambda(2S) = 34) to further siblings of affected sibling pairs. Complex segregation analysis using POINTER and COMDS show that all single locus models, as well as polygenic and multifactorial models, provide a significantly (P < 0.001) better fit to the data than a sporadic model. Of the genetic models, the general single locus model was not significantly different from additive or dominant single locus models, all of which gave a gene frequency for the putative disease susceptibility allele of approximately 0.002. The general single locus model was strongly favored (P < 0.001) over a recessive single gene model. Using POINTER, polygenic and multifactorial models were clearly rejected (P < 0.001 in all cases) in favor of the general single locus model. Using COMDS, the analysis was extended to consider two locus m
Who reads Genetic epidemiology of visceral leishmaniasis in northeastern Brazil?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- C.S. Peacock; A. Collins; M.-A. Shaw; F. Silveira; J. Costa; C.H. Coste; M.D. Nascimento; R. Siddiqui; J.J. Shaw; J.M. Blackwell
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0395)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)