Can I read High Frequency Ultrasound Nonlinear Scattering from Porphyrin Nanobubbles on EtoBox?

High Frequency Ultrasound Nonlinear Scattering from Porphyrin Nanobubbles by Carly Pellow; Josephine Tan; Emmanuel Chérin; Christine E.M. Demore; Gang Zheng; David E. Goertz is a Engineering article available to read on EtoBox.

What is High Frequency Ultrasound Nonlinear Scattering from Porphyrin Nanobubbles about?

Emerging contrast imaging studies have highlighted the potential of nanobubbles for both intravascular and extravascular applications. Reports to date on nanobubbles have generally utilized low frequencies ( 10 mL), and B-mode or contrast-mode on preclinical and clinical systems. However, none of these studies directly examined nanobubble acoustic signatures systematically to implement nonlinear imaging schemes in a methodical manner based on nanobubble behaviour. Here, nanobubble nonlinear behaviour is investigated at high frequencies (12.5, 25, 30 MHz) and low concentration (10 mL) in a channel phantom, with different pulse types in single- and multi-pulse sequences to examine behaviour under conditions relevant to high frequency imaging. Porphyrin nanobubbles are demonstrated to initiate nonlinear scattering at high frequencies in a pressure-threshold dependent manner, as previously observed at low frequencies. This threshold behaviour was then utilized to demonstrate enhanced nanobubble imaging with pulse inversion, amplitude modulation, and a combination of the two, progressing towards the improved sensitivity and expanded utility of these ultrasound contrast agents.

Who reads High Frequency Ultrasound Nonlinear Scattering from Porphyrin Nanobubbles?

Author

Carly Pellow; Josephine Tan; Emmanuel Chérin; Christine E.M. Demore; Gang Zheng; David E. Goertz

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0041-624X)

Published

2021

Language

EN

Field

Engineering (Physical Sciences)