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Enhanced angiogenesis in the 3D dynamic responsive implant for inguinal hernia repair ProFlor by Giuseppe Amato; Roberto Puleio; Vito Rodolico; Antonino Agrusa; Pietro Giorgio Calò; Giuseppe Di Buono; Giorgio Romano; Thorsten Goetze is a Medicine article available to read on EtoBox.

What is Enhanced angiogenesis in the 3D dynamic responsive implant for inguinal hernia repair ProFlor about?

## Abstract Biologic response to hernia prostheses represents a continuous source of debate. Conventional hernia meshes, in their typical static, passive configuration have been used for decades to reinforce the herniated abdominal wall. These flat implants, mainly fixated with sutures or tacks, induce poor quality fibrotic ingrowth that shrinks the mesh. In groin hernia repair, flat meshes are applied in the delicate inguinal surrounding where uncontrolled development of a scar plate can impair movement and may incorporate the sensitive nerves crossing this area. Complications deriving from mesh fixation and nerve entrapment are frequent and unpleasant for patients. To remedy these problems, a multilamellar shaped 3D device with a dynamic responsive behavior has recently been developed to repair inguinal hernia. Its inherent dynamic compliance during inguinal movements has shown to induce enhanced biological response with ingrowth of newly formed connective tissue, muscle fibers, and nerves. The function of these highly specialized tissue structures is supported by the contextual development of newly formed arteries and veins. The scope of the study was to assess quantity and qual

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Author

Giuseppe Amato; Roberto Puleio; Vito Rodolico; Antonino Agrusa; Pietro Giorgio Calò; Giuseppe Di Buono; Giorgio Romano; Thorsten Goetze

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)