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The Janus face of pluripotent stem cells – Connection between pluripotency and tumourigenicity by Anna M. Wobus is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Pluripotent stem cells have gained special attraction because of their almost unlimited proliferation and differentiation capacity __in vitro__. These properties substantiate the potential of pluripotent stem cells in basic research and regenerative medicine. Here three types of __in vitro__‐cultured pluripotent stem cells (embryonic carcinoma, embryonic stem and induced pluripotent stem cells) are compared in their historical context with respect to their different origin and properties. It became evident that tumourigenicity is an inherent property of pluripotent cells based on p53 down‐regulation, expression of tumour‐related genes and high telomerase activity that allow unlimited proliferation. In addition, culture‐adapted genetic and epigenetic changes may induce tumourigenicity of pluripotent cells. The use of stem cells in regenerative medicine, however, requires non‐malignant cell types and strategies that circumvent stages of malignancy. Reprogramming strategies of adult somatic cells that avoid the tumourigenic state of pluripotency may offer alternatives for future biomedical application.

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Author

Anna M. Wobus

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0265-9247)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)