Can I read Involvement of DNA polymerase III in UV-induced mutagenesis of bacteriophage lambda on EtoBox?
Involvement of DNA polymerase III in UV-induced mutagenesis of bacteriophage lambda by Anne Brotcorne-Lannoye; Geneviève Maenhaut-Michel; Miroslav Radman is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Involvement of DNA polymerase III in UV-induced mutagenesis of bacteriophage lambda about?
It has been proposed that the mutation fixation processes stimulated by SOS induction result from an induced infidelity of DNA replication (Radman 1974). The aim of this study was to determine if mutator mutations in the E. coli DNA polymerase III might affect UV-induced mutagenesis. Using a phage lambda mutation assay which can discriminate between targeted and untargeted mutations, we show that the polC74 mutator mutation (Sevastopoulos and Glaser 1977) primarily affects untargeted mutagenesis, which occurs in a recA1 genetic background and is amplified in the recA+ genetic background. The polC74 mutation also increases the UV-induced mutagenesis of the bacterial chromosome. These results suggest that DNA polymerase III is involved in the process of UV-induced mutagenesis in E. coli.
Who reads Involvement of DNA polymerase III in UV-induced mutagenesis of bacteriophage lambda?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Anne Brotcorne-Lannoye; Geneviève Maenhaut-Michel; Miroslav Radman
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0026-8925)
- Published
- 1984
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)