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Grape Seed Procyanidins Inhibit the Growth of Breast Cancer MCF-7 Cells by Down-Regulating the EGFR/VEGF/MMP9 Pathway by Fan-ting Kong; Chen-xi He; Fan-lei Kong; Su-fen Han; Xiang-shun Kong; Wei-qiang Han; Li-xian Yang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Grape Seed Procyanidins Inhibit the Growth of Breast Cancer MCF-7 Cells by Down-Regulating the EGFR/VEGF/MMP9 Pathway about?

Breast cancer is the most common invasive cancer in women and the second leading cause of cancer death in women. However, it is not clear about its effective treatments. As a potential anticancer agent, grape seed procyanidins (GSPs) have been shown to inhibit the proliferation of various cancer cells in vitro and in vivo. In this study, it was shown that GSPs significantly inhibit MCF-7 cell proliferation in a concentration/time-dependent manner. The flow cytometric data clearly demonstrated that GSPs cause cell cycle arrest in the G 2 /M phase, followed by cell apoptosis. Moreover, it also confirmed that growth inhibition mediated by treatment with GSPs is related to the induction of apoptosis due to p53 elevation, purportedly by inhibition of the epidermal growth factor receptor (EGFR)/vascular endothelial growth factor (VEGF)/matrix metalloproteinase 9 (MMP9) pathway. Taken together, these findings suggest that GSPs inhibit MCF-7 cells proliferation and induce cell apoptosis by suppressing EGFR/VEGF/ MMP9 pathway.

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Author

Fan-ting Kong; Chen-xi He; Fan-lei Kong; Su-fen Han; Xiang-shun Kong; Wei-qiang Han; Li-xian Yang

Publisher

SAGE Publications

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)