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Self-assembling RADA16 peptide hydrogel supports hemostasis, synechiae reduction, and wound healing in a sheep model of endoscopic nasal surgery by Michael Fook-Ho Lee; Arjuna Ananda is a Medicine article available to read on EtoBox.
What is Self-assembling RADA16 peptide hydrogel supports hemostasis, synechiae reduction, and wound healing in a sheep model of endoscopic nasal surgery about?
## Objectives: Complications of endoscopic sinus/nasal turbinate surgery include postoperative hemorrhage, synechiae formation, and poor wound healing. our primary objectives were to evaluate whether a topical hydrogel based on self-assembling rada16 peptides: i) reduces bleeding and synechiae formation, and ii) supports wound healing, using a sheep nasal surgery model. ## Methods: Thirty sheep received endoscopic surgery-created bilateral nasal mucosal injuries on the middle turbinate/opposing septum. injuries were randomly assigned rada16, gelatin-thrombin, or no treatment. outcomes included intra-operative hemostasis, scar tissue/synechiae formation and wound healing at 2 weeks and the 6-week study terminus, and histopathology. ## Results: Intra-operative hemostasis time improved with rada16 and gelatin-thrombin versus control wounds (139.7±56.2 s, 145.4±58.1 s, and 224.0±69.9 s, respectively; p 0.05), but were reduced in rada16 sites by 91% versus controls and 92% versus gelatin-thrombin treatment (0.3±0.6 points; p 0.05), but reduced 100% in rada16-treated wounds. synechiae occurred in fewer rada16-treated sites at 2 weeks (20%) versus gelatin-thrombin (80%) and controls (
Who reads Self-assembling RADA16 peptide hydrogel supports hemostasis, synechiae reduction, and wound healing in a sheep model of endoscopic nasal surgery?
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- Author
- Michael Fook-Ho Lee; Arjuna Ananda
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)