Skip to content

Opening book details…

Can I read Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors on EtoBox?

Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors by Kunze, Katie L. (author);Johnson, Patrick W. (author);van Helmond, Noud (author);Senefeld, Jonathon W. (author);Petersen, Molly M. (author);Klassen, Stephen A. (author);Wiggins, Chad C. (author);Klompas, Allan M. (author);Bruno, Katelyn A. (author);Mills, John R. (author);Theel, Elitza S. (author);Buras, Matthew R. (author);Golafshar, Michael A. (author);Sexton, Matthew A. (author);Diaz Soto, Juan C. (author);Baker, Sarah E. (author);Shepherd, John R. A. (author);Verdun, Nicole C. (author);Marks, Peter (author);Paneth, Nigel S. (author);Fairweather, DeLisa (author);Wright, R. Scott (author);van Buskirk, Camille M. (author);Winters, Jeffrey L. (author);Stubbs, James R. (author);Senese, Katherine A. (author);Pletsch, Michaela C. (author);Buchholtz, Zachary A. (author);Rea, Robert F. (author);Herasevich, Vitaly (author);Whelan, Emily R. (author);Clayburn, Andrew J. (author);Larson, Kathryn F. (author);Ripoll, Juan G. (author);Andersen, Kylie J. (author);Lesser, Elizabeth R. (author);Vogt, Matthew N. P. (author);Dennis, Joshua J. (author);Regimbal, Riley J. (author);Bauer, Philippe R. (author);Blair, Janis E. (author);Casadevall, Arturo (author);Carter, Rickey E. (author);Joyner, Michael J. (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors about?

Successful therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have harnessed the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence that SARS-CoV-2 exists as locally evolving variants suggests that immunological differences may impact the effectiveness of antibody-based treatments such as convalescent plasma and vaccines. Considering that near-sourced convalescent plasma likely reflects the antigenic composition of local viral strains, we hypothesize that convalescent plasma has a higher efficacy, as defined by death within 30 days of transfusion, when the convalescent plasma donor and treated patient were in close geographic proximity. Results of a series of modeling techniques applied to approximately 28,000 patients from the Expanded Access to Convalescent Plasma program (ClinicalTrials.gov number: NCT04338360) support this hypothesis. This work has implications for the interpretation of clinical studies, the ability to develop effective COVID-19 treatments, and, potentially, for the effectiveness of COVID-19 vaccines as additional locally-evolving variants continue to emerge.

Who reads Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors?

It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.

Author
Kunze, Katie L. (author);Johnson, Patrick W. (author);van Helmond, Noud (author);Senefeld, Jonathon W. (author);Petersen, Molly M. (author);Klassen, Stephen A. (author);Wiggins, Chad C. (author);Klompas, Allan M. (author);Bruno, Katelyn A. (author);Mills, John R. (author);Theel, Elitza S. (author);Buras, Matthew R. (author);Golafshar, Michael A. (author);Sexton, Matthew A. (author);Diaz Soto, Juan C. (author);Baker, Sarah E. (author);Shepherd, John R. A. (author);Verdun, Nicole C. (author);Marks, Peter (author);Paneth, Nigel S. (author);Fairweather, DeLisa (author);Wright, R. Scott (author);van Buskirk, Camille M. (author);Winters, Jeffrey L. (author);Stubbs, James R. (author);Senese, Katherine A. (author);Pletsch, Michaela C. (author);Buchholtz, Zachary A. (author);Rea, Robert F. (author);Herasevich, Vitaly (author);Whelan, Emily R. (author);Clayburn, Andrew J. (author);Larson, Kathryn F. (author);Ripoll, Juan G. (author);Andersen, Kylie J. (author);Lesser, Elizabeth R. (author);Vogt, Matthew N. P. (author);Dennis, Joshua J. (author);Regimbal, Riley J. (author);Bauer, Philippe R. (author);Blair, Janis E. (author);Casadevall, Arturo (author);Carter, Rickey E. (author);Joyner, Michael J. (author)
Publisher
Springer Science and Business Media LLC
Published
2021
Language
EN
Field
Biochemistry, Genetics and Molecular Biology (Life Sciences)

More by Kunze, Katie L. (author);Johnson, Patrick W. (author);van Helmond, Noud (author);Senefeld, Jonathon W. (author);Petersen, Molly M. (author);Klassen, Stephen A. (author);Wiggins, Chad C. (author);Klompas, Allan M. (author);Bruno, Katelyn A. (author);Mills, John R. (author);Theel, Elitza S. (author);Buras, Matthew R. (author);Golafshar, Michael A. (author);Sexton, Matthew A. (author);Diaz Soto, Juan C. (author);Baker, Sarah E. (author);Shepherd, John R. A. (author);Verdun, Nicole C. (author);Marks, Peter (author);Paneth, Nigel S. (author);Fairweather, DeLisa (author);Wright, R. Scott (author);van Buskirk, Camille M. (author);Winters, Jeffrey L. (author);Stubbs, James R. (author);Senese, Katherine A. (author);Pletsch, Michaela C. (author);Buchholtz, Zachary A. (author);Rea, Robert F. (author);Herasevich, Vitaly (author);Whelan, Emily R. (author);Clayburn, Andrew J. (author);Larson, Kathryn F. (author);Ripoll, Juan G. (author);Andersen, Kylie J. (author);Lesser, Elizabeth R. (author);Vogt, Matthew N. P. (author);Dennis, Joshua J. (author);Regimbal, Riley J. (author);Bauer, Philippe R. (author);Blair, Janis E. (author);Casadevall, Arturo (author);Carter, Rickey E. (author);Joyner, Michael J. (author)

Browse all works by Kunze, Katie L. (author);Johnson, Patrick W. (author);van Helmond, Noud (author);Senefeld, Jonathon W. (author);Petersen, Molly M. (author);Klassen, Stephen A. (author);Wiggins, Chad C. (author);Klompas, Allan M. (author);Bruno, Katelyn A. (author);Mills, John R. (author);Theel, Elitza S. (author);Buras, Matthew R. (author);Golafshar, Michael A. (author);Sexton, Matthew A. (author);Diaz Soto, Juan C. (author);Baker, Sarah E. (author);Shepherd, John R. A. (author);Verdun, Nicole C. (author);Marks, Peter (author);Paneth, Nigel S. (author);Fairweather, DeLisa (author);Wright, R. Scott (author);van Buskirk, Camille M. (author);Winters, Jeffrey L. (author);Stubbs, James R. (author);Senese, Katherine A. (author);Pletsch, Michaela C. (author);Buchholtz, Zachary A. (author);Rea, Robert F. (author);Herasevich, Vitaly (author);Whelan, Emily R. (author);Clayburn, Andrew J. (author);Larson, Kathryn F. (author);Ripoll, Juan G. (author);Andersen, Kylie J. (author);Lesser, Elizabeth R. (author);Vogt, Matthew N. P. (author);Dennis, Joshua J. (author);Regimbal, Riley J. (author);Bauer, Philippe R. (author);Blair, Janis E. (author);Casadevall, Arturo (author);Carter, Rickey E. (author);Joyner, Michael J. (author)