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The clinical significance of soluble CD86 levels in patients with acute myeloid leukemia and myelodysplastic syndrome by Barry D. Hock; Judith L. McKenzie; William Nigel Patton; Lisa F. Haring; Ying Yang; Yu Shen; Elihu H. Estey; Maher Albitar is a Medicine article available to read on EtoBox.
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## Abstract ## BACKGROUND Levels of the soluble form of CD86 (sCD86) are elevated in a proportion of patients with leukemia. Although it is a potential modulator of antitumor responses, the significance of sCD86 in patients with hematologic malignancies is unknown. ## METHODS The authors evaluated sCD86 levels by enzyme‐linked immunosorbent assay in patients with acute myeloid leukemia (AML) (__n__ = 57 patients) and patients with myelodysplastic syndrome (MDS) (__n__ = 40 patients) and analyzed the relation between sCD86 levels and various clinical parameters. ## RESULTS Levels of sCD86 were elevated (> 2.32 ng/mL) relative to normal donors (0.22–2.32 ng/mL; __n__ = 51 patients) in 25% of patients with AML and in 27% of patients with MDS. Patients with AML who had elevated sCD86 levels had significantly lower complete remission (CR) rates compared with patients with AML who had normal sCD86 levels. In multivariate analysis using sCD86 as a continuous variable and including the interaction of age and sCD86 as a variable, sCD86 was a significant prognostic factor (__P__ = 0.014) independent of cytogenetics. Further analysis demonstrated that, in patients with AML age 60 years and yo
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- Author
- Barry D. Hock; Judith L. McKenzie; William Nigel Patton; Lisa F. Haring; Ying Yang; Yu Shen; Elihu H. Estey; Maher Albitar
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)