Can I read Modeling Immune Complex-mediated Autoimmune Inflammation on EtoBox?

Modeling Immune Complex-mediated Autoimmune Inflammation by A. Arazi; A.U. Neumann is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Modeling Immune Complex-mediated Autoimmune Inflammation about?

A number of autoimmune diseases are thought to feature a particular type of self-sustaining inflammation, caused by the deposition of immune complexes (IC) in the inflamed tissue and a consequent activation of local effector cells. The persistence of this inflammation is due to a positive feedback loop, where autoantigen particles released as part of the tissue damage caused by the inflammation stimulate autoreactive B cells, leading to the formation of further immune complexes and their subsequent deposition. We present a mathematical model for the exploration of IC-mediated autoimmune inflammation and its clinical implications. We characterize the possible differences between normal individuals and those susceptible to such inflammation, and show that both random perturbations and bifurcations can lead to disease onset. Our model explains how defects in the mechanisms responsible for cellular debris clearance contribute to the development of disease, in agreement with empirical evidence. Moreover, we show that parameters governing the dynamics of immune complexes, such as their clearance rate, have an even stronger effect in determining the behavior of the system. We demonstrate

Who reads Modeling Immune Complex-mediated Autoimmune Inflammation?

Author

A. Arazi; A.U. Neumann

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-5193)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)