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Biexponential parameterization of diffusion and T~2~ relaxation decay curves in a rat muscle edema model: Decay curve components and water compartments by Zaid Ababneh; Helene Beloeil; Charles B. Berde; Giulio Gambarota; Stephan E. Maier; Robert V. Mulkern is a Medicine article available to read on EtoBox.

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## Abstract Quantitative T~2~ relaxation and diffusion imaging studies of a rat muscle edema model were performed in order to determine the effects of intra‐ and extracellular water compartmentation on the respective decay curves. The right hind paw of rats was injected with a carrageenan solution to generate edematous muscle. A Carr–Purcell–Meiboom–Gill (CPMG) imaging sequence was used to acquire T~2~ relaxation decay curves from both paws. A line scan diffusion imaging (LSDI) sequence was then used to acquire diffusion decay curves from the same paws over a wide b‐factor range. Measurements were made from both edematous muscle (EM) and control muscle (CM). The EM and CM T~2~ relaxation decay curves were best fit with biexponential functions. The fraction of the fast T~2~ component dropped dramatically from approximately 0.95 in CM to 0.45 in EM, consistent with a water compartmentation model in which the fast and slow T~2~ components reflect intra‐ and extracellular water, respectively. Both CM and EM diffusion decay curves required biexponential fitting functions, and the diffusion coefficients of the fast and slow components were substantially larger in EM than CM. The fraction

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Author

Zaid Ababneh; Helene Beloeil; Charles B. Berde; Giulio Gambarota; Stephan E. Maier; Robert V. Mulkern

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2005

Language

EN

Field

Medicine (Health Sciences)