Can I read Engineered smart materials for RNA based molecular therapy to treat Glioblastoma on EtoBox?

Engineered smart materials for RNA based molecular therapy to treat Glioblastoma by Ravi Raj Singh; Indranil Mondal; Taskeen Janjua; Amirali Popat; Ritu Kulshreshtha is a Engineering article available to read on EtoBox.

What is Engineered smart materials for RNA based molecular therapy to treat Glioblastoma about?

Glioblastoma (GBM) is an aggressive malignancy of the central nervous system (CNS) that remains incurable despite the multitude of improvements in cancer therapeutics. The conventional chemo and radiotherapy post-surgery have only been able to improve the prognosis slightly; however, the development of resistance and/or tumor recurrence is almost inevitable. There is a pressing need for adjuvant molecular therapies that can successfully and efficiently block tumor progression. During the last few decades, non-coding RNAs (ncRNAs) have emerged as key players in regulating various hallmarks of cancer including that of GBM. The levels of many ncRNAs are dysregulated in cancer, and ectopic modulation of their levels by delivering antagonists or overexpression constructs could serve as an attractive option for cancer therapy. The therapeutic potential of several types of ncRNAs, including miRNAs, lncRNAs, and circRNAs, has been validated in both __in vitro__ and __in vivo__ models of GBM. However, the delivery of these RNA-based therapeutics is highly challenging, especially to the tumors of the brain as the blood-brain barrier (BBB) poses as a major obstacle, among others. Also, since

Who reads Engineered smart materials for RNA based molecular therapy to treat Glioblastoma?

Author

Ravi Raj Singh; Indranil Mondal; Taskeen Janjua; Amirali Popat; Ritu Kulshreshtha

Publisher

Elsevier BV

Published

2024

Language

EN

Field

Engineering (Physical Sciences)