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The Relationship Between Biological Rhythms And Mitochondrial Dysfunction In Bipolar I Disorder by Sai Sruthi Amirtha Ganesh; Nuno Raimundo; Robert Gonzalez; Suzanne Gonzalez is a Medicine article available to read on EtoBox.

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s (AUC = 0.87) demonstrated enrichment for drugs approved to treat them. Discussion: These results establish that drug gene-set analysis can identify clinically relevant drugs -with accuracy varying across the phenotypes we examined -and offer new drug candidates for repurposing. Drug gene-set analysis can successfully identify drugs enriched with genetic signal for a given phenotype. Moreover, phenotypes where no drugs were prioritized or no enrichment was found may not reflect a shortcoming of drug gene-set analysis, but the gap between the genes targeted by current treatments and the genes most associated with a phenotype as measured by GWAS. Given the excessive financial and time investments facing psychiatric drug development, an in-silico, cheap, and quick method for genetically informed drug repurposing, such as drug gene-set analysis, may prove invaluable.

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Author

Sai Sruthi Amirtha Ganesh; Nuno Raimundo; Robert Gonzalez; Suzanne Gonzalez

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Life Sciences)