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Protection Against Dopaminergic Nigrostriatal Cell Death by Excitatory Input Ablation by M. Takada; M. Matsumura; J. Kojima; Y. Yamaji; M. Inase; H. Tokuno; A. Nambu; H. Imai is a Neuroscience article available to read on EtoBox.

What is Protection Against Dopaminergic Nigrostriatal Cell Death by Excitatory Input Ablation about?

The importance of enhanced glutamatergic neurotransmission in the basal ganglia and related structures has recently been highlighted in the development of Parkinson's disease. The pedunculopontine tegmental nucleus (PPN) is the major origin of excitatory, glutamatergic input to dopaminergic nigrostriatal neurons of which degeneration is well known to cause Parkinson's disease. Based on the concept that an excitatory mechanism mediated by glutamatergic neurotransmission underlies the pathogenesis of neurodegenerative disorders, we made an attempt to test the hypothesis that removal of the glutamatergic input to the nigrostriatal neurons by PPN lesions might prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the macaque monkey. The PPN was lesioned unilaterally with microinjection of kainic acid, and, then, MPTP was administered systemically. In these monkeys, the degree of parkinsonian motor signs was behaviourally evaluated, and the histological changes in the dopaminergic nigrostriatal system were analysed by means of tyrosine hydroxylase immunohistochemistry. The present results revealed that nigrostriatal cell loss and parkinsonian motor deficits

Who reads Protection Against Dopaminergic Nigrostriatal Cell Death by Excitatory Input Ablation?

Author

M. Takada; M. Matsumura; J. Kojima; Y. Yamaji; M. Inase; H. Tokuno; A. Nambu; H. Imai

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2000

Language

EN

Field

Neuroscience (Life Sciences)