About this Biochemistry, Genetics and Molecular Biology article

Apelin/APJ system: an emerging therapeutic target for respiratory diseases by Jialong Yan; Aiping Wang; Jiangang Cao; Linxi Chen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

Apelin is an endogenous ligand of G protein-coupled receptor APJ. It is extensively expressed in many tissues such as heart, liver, and kidney, especially in lung tissue. A growing body of evidence suggests that apelin/APJ system is closely related to the development of respiratory diseases. Therefore, in this review, we focus on the role of apelin/APJ system in respiratory diseases, including pulmonary arterial hypertension (PAH), pulmonary embolism (PE), acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), obstructive sleep apnoea syndrome (OSAS), non-small cell lung cancer (NSCLC), pulmonary edema, asthma, and chronic obstructive pulmonary diseases. In detail, apelin/APJ system attenuates PAH by activating AMPK-KLF2-eNOS-NO signaling and miR424/503-FGF axis. Also, apelin protects against ALI/ARDS by reducing mitochondrial ROS-triggered oxidative damage, mitochondria apoptosis, and inflammatory responses induced by the activation of NF-κB and NLRP3 inflammasome. Apelin/APJ system also prevents the occurrence of pulmonary edema via activating AKT-NOS3-NO pathway. Moreover, apelin/APJ system accelerates NSCLC cells' proliferation and migration via triggering ERK1/2-c

Author

Jialong Yan; Aiping Wang; Jiangang Cao; Linxi Chen

Publisher

Springer Science and Business Media LLC

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)