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Cardiac injury modulates critical components of prostaglandin E~2~ signaling during zebrafish heart regeneration by FitzSimons, MaryLynn; Beauchemin, Megan; Smith, Ashley M.; Stroh, Erika G.; Kelpsch, Daniel J.; Lamb, Maureen C.; Tootle, Tina L.; Yin, Viravuth P. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract The inability to effectively stimulate cardiomyocyte proliferation remains a principle barrier to regeneration in the adult human heart. A tightly regulated, acute inflammatory response mediated by a range of cell types is required to initiate regenerative processes. Prostaglandin E~2~ (PGE~2~), a potent lipid signaling molecule induced by inflammation, has been shown to promote regeneration and cell proliferation; however, the dynamics of PGE~2~ signaling in the context of heart regeneration remain underexplored. Here, we employ the regeneration-competent zebrafish to characterize components of the PGE~2~ signaling circuit following cardiac injury. In the regenerating adult heart, we documented an increase in PGE~2~ levels, concurrent with upregulation of cox2a and ptges, two genes critical for PGE~2~ synthesis. Furthermore, we identified the epicardium as the most prominent site for cox2a expression, thereby suggesting a role for this tissue as an inflammatory mediator. Injury also drove the opposing expression of PGE~2~ receptors, upregulating pro-restorative ptger2a and downregulating the opposing receptor ptger3. Importantly, treatment with pharmacological inhibito
Who reads Cardiac injury modulates critical components of prostaglandin E~2~ signaling during zebrafish heart regeneration?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- FitzSimons, MaryLynn; Beauchemin, Megan; Smith, Ashley M.; Stroh, Erika G.; Kelpsch, Daniel J.; Lamb, Maureen C.; Tootle, Tina L.; Yin, Viravuth P.
- Publisher
- Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)