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ChemInform Abstract: Design and Biological Evaluation of a Series of Thiophene‐Based 3‐ Hydroxy‐3‐methylglutaryl Coenzyme A Reductase Inhibitors. by G. M. COPPOLA; R. E. DAMON; H. YU; R. G. ENGSTROM; T. J. SCALLEN is a Chemistry article available to read on EtoBox.

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Design and Biological Evaluation of a Series of Thiophene-Based 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors. -The target compounds (VII) are prepared starting from thiophenes (I) including aldol condensation and subsequent stereocontrolled reduction of the β-ketoester function to give (VI). Among a great variety of sodium carboxylates (VII) the here pictured ones show high HMG-CoA reductase inhibitory activity. The most potent derivative is compound ( VIIb). -(COPPOLA, G. M.; DAMON,

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Author

G. M. COPPOLA; R. E. DAMON; H. YU; R. G. ENGSTROM; T. J. SCALLEN

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley (ISSN 0931-7597)

Published

1997

Language

EN

Field

Chemistry (Physical Sciences)