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Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group by Allen Eng-Juh Yeoh; Yi Lu; Jason Yong-Sheng Chan; Yiong Huak Chan; Hany Ariffin; Shirley Kow-Yin Kham; Thuan Chong Quah is a Medicine article available to read on EtoBox.
What is Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group about?
To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers marginal protection. Interestingly, we observed that NQO1 609CT and MTHFR 1298 C-allele have greater genetic impact in boys than in girls. The combination of SLC19A1 80GA heterozygosity and 3'-TYMS -6bp/-6bp homozygous deletion is associated with reduced ALL risk in Malay boys. Our study has suggested the importance of gender and race in modulating ALL susceptibility via the folate metabolic pathway.
Who reads Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group?
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- Author
- Allen Eng-Juh Yeoh; Yi Lu; Jason Yong-Sheng Chan; Yiong Huak Chan; Hany Ariffin; Shirley Kow-Yin Kham; Thuan Chong Quah
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0145-2126)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)