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A Long Lasting Oral Preformulation of The Angiotensin II AT1 Receptor Antagonist Losartan by Washington Xavier de Paula is a document available to read on EtoBox.
The study investigates a long-lasting oral preformulation of losartan, an angiotensin II AT1 receptor antagonist, using a host:guest strategy with beta-cyclodextrin (bCD) to enhance its bioavailability. Results indicate that the losartan/bCD complex provides a sustained release effect, maintaining plasma levels and antihypertensive efficacy for up to 72 hours compared to 6 hours for losartan alone. This formulation could potentially reduce dosing frequency and improve patient compliance in managing hyperten
- Author
- Washington Xavier de Paula
- Language
- EN