Can I read Serum soluble Fas levels and prediction of response to platinum‐based chemotherapy in epithelial ovarian cancer on EtoBox?

Serum soluble Fas levels and prediction of response to platinum‐based chemotherapy in epithelial ovarian cancer by Parvesh Chaudhry; Radhika Srinivasan; Firuza D Patel; Sarala Gopalan; Siddhartha Majumdar is a Medicine article available to read on EtoBox.

What is Serum soluble Fas levels and prediction of response to platinum‐based chemotherapy in epithelial ovarian cancer about?

## Abstract Epithelial ovarian cancer (EOC) is treated mainly by platinum‐based combination chemotherapy. Chemotherapy induces apoptosis in which the Fas/Fas ligand pathway is important. Serum soluble Fas (sFas) is a biomarker of this pathway and functionally inhibits Fas‐/FasL‐mediated apoptosis. In this study, we have investigated the role of sFas in prediction of response to chemotherapy in EOC. Thirty‐five patients were recruited and their serum sFas levels were estimated by ELISA at 4 time points—preoperative (sFas1), postoperative (sFas2), midchemotherapy (sFas3) and at the end of chemotherapy (sFas4). The response to chemotherapy was documented clinically, radiologically and by CA‐125 levels, based on which, 2 groups were identified: primary chemosensitive (__n__ = 24) and primary chemoresistant (__n__ = 11). Based on the disease status at last follow‐up, 2 groups were identified: No Evidence of Disease (__n__ = 15) and Evidence of Disease (__n__ = 20). The primary chemoresistant tumors showed significantly higher median sFas2 levels (__p__ = 0.033) with the sFas2/sFas1 ratio ≥1 (__p__ = 0.001). A multivariate Cox proportional hazards regression model identified sFas2/sFas1

Who reads Serum soluble Fas levels and prediction of response to platinum‐based chemotherapy in epithelial ovarian cancer?

Author

Parvesh Chaudhry; Radhika Srinivasan; Firuza D Patel; Sarala Gopalan; Siddhartha Majumdar

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2007

Language

EN

Field

Medicine (Health Sciences)