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Accuracy and applications of group MEG studies using cortical source locations estimated from participants' scalp surfaces by Ian E. Holliday; Gareth R. Barnes; Arjan Hillebrand; Krish D. Singh is a Neuroscience article available to read on EtoBox.

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## Abstract We contend that powerful group studies can be conducted using magnetoencephalography (MEG), which can provide useful insights into the approximate distribution of the neural activity detected with MEG without requiring magnetic resonance imaging (MRI) for each participant. Instead, a participant's MRI is approximated with one chosen as a best match on the basis of the scalp surface from a database of available MRIs. Because large inter‐individual variability in sulcal and gyral patterns is an inherent source of blurring in studies using grouped functional activity, the additional error introduced by this approximation procedure has little effect on the group results, and offers a sufficiently close approximation to that of the participants to yield a good indication of the true distribution of the grouped neural activity. T1‐weighted MRIs of 28 adults were acquired in a variety of MR systems. An artificial functional image was prepared for each person in which eight 5 × 5 × 5 mm regions of brain activation were simulated. Spatial normalisation was applied to each image using transformations calculated using SPM99 with (1) the participant's actual MRI, and (2) the best m

Who reads Accuracy and applications of group MEG studies using cortical source locations estimated from participants' scalp surfaces?

Author

Ian E. Holliday; Gareth R. Barnes; Arjan Hillebrand; Krish D. Singh

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1065-9471)

Published

2003

Language

EN

Field

Neuroscience (Life Sciences)