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Calcitonin Gene-related Peptide in Gingival Crevicular Fluid in Periodontal Health and Disease by Fionnuala T. Lundy; Christopher Shaw; Judith McKinnell; Philip-J. Lamey; Gerard J. Linden is a Dentistry article available to read on EtoBox.

What is Calcitonin Gene-related Peptide in Gingival Crevicular Fluid in Periodontal Health and Disease about?

__Abstract__. The aims of the present study were to investigate whether calcitonin gene‐related peptide (CGRP) was present in gingival crevicular fluid in both periodontal health and disease and to study the relationship with periodontal inflammation. Gingival crevicular fluid (GCF) was collected from a healthy, a gingivitis and a periodontitis site in 18 subjects with periodontitis and from a healthy site in 19 subjects without periodontitis. The volume of GCF was measured and each sample subsequently analysed for CGRP by radioimmunoassay. In subjects with periodontitis, CGRP immunoreactivity (CGRP‐IR) was not detected in any periodontitis sites, nor in 67% of gingivitis and 28% of periodontallyhealthy sites. The total amount of CGRP‐IR was significantly elevated in periodontally healthy (__p__=0.0015) and gingivitis (__p__=0.027) compared with periodontitis sites. CGRP‐IR was present in 89% of the healthy sites sampled in control subjects at comparable levels to those in healthy sites in periodontitis subjects. It is concluded that in periodontal inflammation, particularly in deep pockets, constituents of GCF process and degrade CGRP.

Who reads Calcitonin Gene-related Peptide in Gingival Crevicular Fluid in Periodontal Health and Disease?

Author

Fionnuala T. Lundy; Christopher Shaw; Judith McKinnell; Philip-J. Lamey; Gerard J. Linden

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0303-6979)

Published

1999

Language

EN

Field

Dentistry (Health Sciences)