Can I read Reconstruction of the Yeast Protein-protein Interaction Network Involved in Nutrient Sensing and Global Metabolic Regulation on EtoBox?

Reconstruction of the Yeast Protein-protein Interaction Network Involved in Nutrient Sensing and Global Metabolic Regulation by Subir K Nandy; Paula Jouhten; Jens Nielsen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Reconstruction of the Yeast Protein-protein Interaction Network Involved in Nutrient Sensing and Global Metabolic Regulation about?

## Abstract ## Background Several protein-protein interaction studies have been performed for the yeast __Saccharomyces cerevisiae__ using different high-throughput experimental techniques. All these results are collected in the BioGRID database and the SGD database provide detailed annotation of the different proteins. Despite the value of BioGRID for studying protein-protein interactions, there is a need for manual curation of these interactions in order to remove false positives. ## Results Here we describe an annotated reconstruction of the protein-protein interactions around four key nutrient-sensing and metabolic regulatory signal transduction pathways (STP) operating in __Saccharomyces cerevisiae__. The reconstructed STP network includes a full protein-protein interaction network including the key nodes Snf1, Tor1, Hog1 and Pka1. The network includes a total of 623 structural open reading frames (ORFs) and 779 protein-protein interactions. A number of proteins were identified having interactions with more than one of the protein kinases. The fully reconstructed interaction network includes all the information available in separate databases for all the proteins included in t

Who reads Reconstruction of the Yeast Protein-protein Interaction Network Involved in Nutrient Sensing and Global Metabolic Regulation?

Author

Subir K Nandy; Paula Jouhten; Jens Nielsen

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2006]-; Springer Science and Business Media LLC (ISSN 1752-0509)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)