Can I read Five Year Results of US Intergroup/RTOG 9704 with Postoperative Ca 19-9 ≤90 and Comparison to the Conko-001 Trial on EtoBox?

Five Year Results of US Intergroup/RTOG 9704 with Postoperative Ca 19-9 ≤90 and Comparison to the Conko-001 Trial by A.C. Berger; K. Winter; J.P. Hoffman; W.F. Regine; R.A. Abrams; H. Safran; G.M. Freedman; A.B. Benson; J. MacDonald; C. Willet is a Medicine article available to read on EtoBox.

What is Five Year Results of US Intergroup/RTOG 9704 with Postoperative Ca 19-9 ≤90 and Comparison to the Conko-001 Trial about?

Purpose/Objective(s): Standard neoadjuvant 6 week chemoradiation (CRT) may delay and reduce tolerability of adjuvant gemcitabine-based chemotherapy for patients with resectable pancreatic ductal adenocarcinoma (PDAC). We explore the safety and efficacy of a one-week course of pre-op CRT with proton beam therapy (PBT) and cape followed by early pancreaticoduodenectomy (PD). Materials/Methods: Patients with radiographically resectable, biopsy-proven PDAC of the head were enrolled from May 2007-March 2010 on this IRB-approved, NCI-sponsored clinical trial. Eligibility included no CT involvement of SMA or celiac artery; adequate renal, hepatic and hematopoietic function; and ECOG PS 0/1. Dose level 1 consisted of PBT delivered 3 Gy x 10 Monday to Friday. Pts in subsequent dose levels received 5 Gy x 5 in progressively shortened schedules: level 2 (wk 1 M W F, wk 2 T Th), level 3 (wk 1 M T Th F, wk 2 M), level 4 (wk 1 M-F). Proton beam therapy was targeted at pancreatic mass with elective nodal coverage. Pts received capecitabine (cape) 825 mg/m2 BID wk 1 and 2 M-F. Surgery was performed 1-6 wks after completion of chemotherapy. Patients were recommended to receive 6 mo of gemcitabine a

Who reads Five Year Results of US Intergroup/RTOG 9704 with Postoperative Ca 19-9 ≤90 and Comparison to the Conko-001 Trial?

Author

A.C. Berger; K. Winter; J.P. Hoffman; W.F. Regine; R.A. Abrams; H. Safran; G.M. Freedman; A.B. Benson; J. MacDonald; C. Willet

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2010

Language

EN

Field

Medicine (Health Sciences)